Two sample MR report
ERAP2_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | -0.0357609 | 0.1031996 | 0.7361313 |
| Weighted median | 12 | -0.0489224 | 0.0148117 | 0.0009567 |
| Inverse variance weighted | 12 | -0.0427288 | 0.0117703 | 0.0002832 |
| Simple mode | 12 | -0.0527381 | 0.0229985 | 0.0425445 |
| Weighted mode | 12 | -0.0525364 | 0.0238138 | 0.0495524 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.765829 | 10 | 0.9978403 |
| Inverse variance weighted | 1.770447 | 11 | 0.9991540 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0056257 | 0.0827772 | 0.9471554 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005197 | 0 | TRUE | 0.0302059 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
